Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1994-08-24
1996-04-09
Adams, Donald E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303872, 5303911, 5303913, 5303915, 530402, 530404, A61K 3516, A61K 3900, C07K 1600
Patent
active
055063420
ABSTRACT:
Methods for preparing metabolically stable, covalently crosslinked F(ab').sub.2 fragments of antibody molecules for use in labeled form as in vivo diagnostic and therapeutic agents, the stabilized F(ab').sub.2 fragments so produced in free form or conjugated to a chemical moiety, kits containing such fragments, and methods of using these fragments for diagnosis or therapy, are disclosed. In the method, crosslinking is carried out after reduction of inter-heavy chain disulfide bonds, but before cleavage of the crosslinked antibody to produce the F(ab').sub.2 molecules.
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Goldberg et al. Bioconjugate Chem 2:275-280 (1991).
Lamk M. Lamki et al., "Metastatic Colorectal Cancer: Radioimmunoscintigraphy with a Stabilized In-111-labeled F(ab').sub.2 Fragment of an Anti-CEA Monoclonal Antibody.sup.1 ", Jan. 1990, vol. 174, pp. 147-151.
Ewa Wasylewska et al., "Stabilization of Human Prostate Acid Phosphatase By Cross-Linking With Diimidoesters", Feb. 1987, vol. 34, pp. 145-156.
D. Scott Wilbur et al., "Development of a Stable Radioiodinating Reagent to Label Monoclonal Antibodies for Radiotherapy of Cancer", Feb. 1989, vol. 30, pp. 216-226.
Glennie et al J. Immunology 139:2367-2375 1987.
Bottino Becky J.
Reno John M.
Adams Donald E.
NeoRx Corporation
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