Stabilized aminophylline solution and process therefor

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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A61K 3152

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active

040739074

ABSTRACT:
A stable aqueous aminophylline solution is provided by admixing with said solution disodium edetate as a chelating agent and removing substantially all the carbon dioxide from the solution. In a preferred manner the chelating agent is present in an amount of 0.01 to 1.0% by weight of the solution. Carbon dioxide is preferably removed to optimize aminophylline stability by boiling the solution under an inert gas protection. A stabilized aqueous aminophylline solution results which can be packaged in a container system which would otherwise have a propensity to develop undesired crystal growth in the solution.

REFERENCES:
drug & Cosmetic Industry, Feb. 1968, pp. 43-46 and 147-149.

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