Stabilized adjuvant suspension comprising dimethyl dioctadecyl a

Details Stabilized adjuvant suspension comprising dimethyl dioctadecyl a Stabilized adjuvant suspension comprising dimethyl dioctadecyl a

1987-12-17

1991-06-25

Moskowitz, Margaret

Drug, bio-affecting and body treating compositions

Lymphokine

424 89, 424 90, 424 91, 424 92, 424 93, 424486, 424487, 514 2, 514 8, 514 10, 514 12, 514642, 514742, A61K 3939, A61K 3178, A61K 4714, A61K 4732

Patent

active

050265466

ABSTRACT:
A stabilized aqueous adjuvant suspension of dimethyl dioctadecyl ammonium bromide stabilized with at least 0.1 part by weight of a polymer of acrylic acid crosslinked with polyallyl sucrose per part by weight of dimethyl dioctadecyl ammonium bromide, plus
a method of stabilizing vaccines adjuvanted with such dimethyl dioctadecyl ammonium bromide.

REFERENCES:
Van Houte et al., Immunology, 43, 627-634, (1981).
Snippe et al., Immunology, 39, 399-405, (1980).
Norimov et al., Biol. Abs., 78(8), Abs, 62153, (1984).
Norimov et al., Biol. Abs., 78(1), Abs. 3597, (1984).

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