Stabilization of the enzyme urate oxidase in liquid form

Details Stabilization of the enzyme urate oxidase in liquid form Stabilization of the enzyme urate oxidase in liquid form

1992-05-07

1993-11-30

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Stablizing an enzyme by forming a mixture, an adduct or a...

435 10, 435189, 435191, C12Q 162, C12N 996, C12N 902, C12N 906

Patent

active

052664724

ABSTRACT:
This invention relates to a process for stabilizing the enzyme urate oxidase (commonly known as uricase) in liquid form, and to the relative compositions which can then be obtained, with particular reference to compositions containing a Trinder reagent. According to the process of the invention, uricase can be stabilized in liquid form by adding to the composition containing the enzyme a substituted or unsubstituted dicarboxylic acid containing from 2 to 5 carbon atoms, and preferably 4 or 5. Aspartic acid has shown to be particularly effective in providing said stabilizing activity in liquid uricase compositions containing a Trinder reagent.

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Wang et al. (1988) J. Parenteral Sci. Tech. (Supp.), 42, S1-S26.

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