Stabilization of somatotropins by modification of cysteine resid

Details Stabilization of somatotropins by modification of cysteine resid Stabilization of somatotropins by modification of cysteine resid

1995-05-09

1999-04-06

Patterson, Jr., Charles L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 530399, 424423, A61K 3827, C07K 1461

Patent

active

058918400

ABSTRACT:
Novel modified or derivatized recombinant animal somatotropins. Methods for stabilizing recombinant animal somatotropins by modification or deletion of the Cysteine residues utilizing site directed mutagenesis to replace from one to four of the cysteine amino acid residues of said somatotropins with one or more different amino acid residues or by derivatization of (1) both cysteine amino acid residues in the small loop of said somatotropin, both cysteine amino acid residues in the large loop or the four cysteine amino acid residues in both loops of said somatotropin.

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