Stabilization of solid thyroid drug formulations

Details Stabilization of solid thyroid drug formulations Stabilization of solid thyroid drug formulations

2005-02-15

2005-02-15

Page, Thurman K. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

C424S451000, C424S484000, C424S486000, C424S488000, C424S489000, C424S494000, C424S495000

Reexamination Certificate

active

06855333

ABSTRACT:
Pharmaceutical formulations and dosage forms are provided having improved stability to moisture-induced degradation when compared with conventional dosage forms, especially tablets. The invention features low compression forms of thyroid drugs together with excipients, preferably in encapsulated forms. In other embodiments, relatively non-volatile oils can be admixed with the drug and/or the excipients to stabilize the formulation toward moisture-induced degradation. Hydrophobic powders are also optionally added to the formulations.

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