Stabilization of retinoid compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

Reexamination Certificate

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C514S947000, C424S489000

Reexamination Certificate

active

06844364

ABSTRACT:
The present invention relates to a method of administering a compound of Formula I:whereinR1is hydrogen or C1-6-alkyl;R2is C1-6-alkyl or adamantyl;R3is C1-6-alkyl or hydroxy; orR2and R3taken together are —(CR6R7)n—;R4is C2-8-alkyl, C2-8-alkenyl, C2-8-alkynyl, —OCH2R5or C2-8-alkanoyl, or hydrogen when R3is hydroxy;R5is C1-6-alkyl, C2-6-alkenyl or C2-6-alkynyl;R6and R7are hydrogen or C1-6-alkyl;Y is oxygen or sulfur; andn is 3, 4, or 5,or a pharmaceutically acceptable salts of carboxylic acid of formula I,wherein said method comprises the step of admixing said compound in solid form with a topical carrier to form a topical formulation within seven days prior to first topical administration of said compound.

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