Stabilization of radiopharmaceutical compositions

Details Stabilization of radiopharmaceutical compositions Stabilization of radiopharmaceutical compositions

1992-06-16

1993-11-16

Stoll, Robert L.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

514970, A61K 4300, A61K 4902

Patent

active

052621758

ABSTRACT:
A method of stabilizing a radiopharmaceutical complex composition is provided comprising the use of an element of Group VII of the Periodic Table selected from technetium, rhenium and manganese, or lanthanum or a transitional metal element or Rare Earth element with Atomic Number of 57 to 71 inclusive that has a range of valency states and an organic complexing compound which is capable of complexing with the radiopharmaceutical element defined above to provide a complex suitable for use in diagnosis and medical treatment, comprising the addition of sufficient of a pharmacologically acceptable weak oxidizing agent to stabilize the radiopharmaceutical complex composition. It is preferred to employ Technetium - 99m as the radiopharmaceutical element, the hemaxmethyl derivative of propyleneamineoxime as the complexing compound and sodium hypochlorite as the weak oxidizing agent. A stabilized composition comprising the same components is also provided.

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