Stabilization of pyrido[3,2-a]phenoxazine compounds

Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Polymer from ethylenic monomers only

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424 80, 424175, 42424853, 42424858, 424280, 544 99, A01N 900, A01N 922, C07D26500, C07D27300

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040924106

ABSTRACT:
Stabilized solutions of 1-hydroxy-5-oxo-5H-pyrido-[3,2-a]-phenoxazine-3-carboxylic acid (I) and of 1,5-dihydroxypyrido-[3,2-a]phenoxazine-3-carboxylic acid (II) are provided. The solutions contain a stabilizer selected from the group consisting of ascorbic acid, isoascorbic acid and water-soluble salts thereof. The solutions optionally contain an auxiliary stabilizer selected from the group consisting of sodium sulfite, sodium metasulfite and N-acetyl-L-cysteine and may also contain a solubilizer.

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