Stabilization of prostaglandin drug

Details Stabilization of prostaglandin drug Stabilization of prostaglandin drug

1997-07-15

1999-03-30

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514964, A61K 31215

Patent

active

058890513

ABSTRACT:
A stable solid dispersion of prostaglandin drug, particularly Misoprostol, (RS)-4-hydroxy-4-methyl-trans-1-octen-1-yl)-oxycyclopent-1.alpha.-yl!hepta noate, comprising ammonio methacrylate copolymers. The ammonio methacrylate copolymers comprise Eudragit RS series, Eudragit RL series, Eudragit S, Eudragit L, and the mixture thereof. The stable solid dispersion is a sustained release type.

REFERENCES:
patent: 3965143 (1976-06-01), Collins et al.
patent: 4301146 (1981-11-01), Sanvordeker
patent: 5232704 (1993-08-01), Franz et al.
Chemical Abstracts :120:330935(C) (Collins et al), 1994.
Chemical Abstracts 110:63733a (Konishi), 1989.
Kislalioglu, M.S. et al., "Physical Characterization and Dissolution Properties of Ibuprofen: Eudragit Coprecipitates," Journal of Pharmaceutical Sciences, pp. 799-804, Aug. 1991.
Yuasa, Hiroshi et al., "Application of the Solid Dispersion Method to Controlled Release of Medicine. I. Controlled Release of Water Soluble Medicine by Using Solid Dispersion," Chemical & Pharmaceutical Bulletin, pp. 465-467, Feb. 1991.

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