Stabilization of phosphorochloridates or thionophosphorochlorida

Chemistry of carbon compounds – Dipeptides – e.g. – aspartame – anserine – carnosine – etc.

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Details

260960, C07F 914, C07F 920

Patent

active

043070418

ABSTRACT:
Phosphorochloridates and thionophosphorochloridates are stabilized against decomposition by the addition of minor amounts of phosphorus pentachloride or the equivalent minor amount of phosphorus trichloride and chlorine. Hydrogen chloride which may be formed is removed by sparging with inert gas. The invention permits the elimination of the customary expensive distillation step previously relied on for production of a stable product to attain commercially acceptable stability to alkyl phosphorochloridates such as diethylphosphorochloridate.

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