Stabilization of phenylalanine ammonia-lyase in a bioreactor usi

Details Stabilization of phenylalanine ammonia-lyase in a bioreactor usi Stabilization of phenylalanine ammonia-lyase in a bioreactor usi

1984-06-06

1986-03-04

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

435188, 435232, C12P 1322, C12N 996, C12N 988

Patent

active

045741174

ABSTRACT:
A method is disclosed for producing L-phenylalanine using, as a catalyst, phenylalanine ammonia-lyase (PAL). Reducing agents are added to a bioreaction mixture containing t-cinnamic acid and ammonia or soluble ammonium salts, in order to reduce the effects of oxygen on catalyst life. The reducing agents of the invention include any substance that lowers the overall electrochemical potential of the solution, or which has a tendency to donate electrons to an oxidizing agent.

REFERENCES:
patent: 4277562 (1981-07-01), Modrovich
Yamada, et al., Production of L-Phenylalanine from trans-Cinnamic Acid with Rhodotorula Glutinis Containing L-Phenylalanine Ammonia-Lyase Activity, Applied and Environmental Microbiology, Nov. 1981, pp. 773-778, vol. 42, No. 5.

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