Stabilization of neutrophils and platelets

Details Stabilization of neutrophils and platelets Stabilization of neutrophils and platelets

1983-06-13

1984-09-11

Rosen, Sam

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

424101, C12N 500, A61K 3514

Patent

active

044710518

ABSTRACT:
Neutrophils and platelets from human blood are stabilized for storage and subsequent reconstitution for use by reacting with a chemical cross-linking agent having functional groups reactive to form covalent linkages with the neutrophils or platelets, the functional groups being covalently bonded to a molecular backbone including a group subject to cleavage under conditions which are non-destructive of the neutrophils or platelets. After storage at reduced temperature, the composition can be reconstituted by cleavage and substantially regains its original physiological properties.

REFERENCES:
patent: 4110161 (1978-08-01), Sekhar
patent: 4344936 (1982-08-01), Soslau
patent: 4390619 (1983-06-01), Pittiglio
patent: 4391909 (1983-07-01), Lim
Kotelba-Witkowska et al., Transfusion, vol. 22, 121-124 (1982).

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