Stabilization of metal conjugates

Details Stabilization of metal conjugates Stabilization of metal conjugates

1997-06-05

1999-10-26

Wortman, Donna C.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is inorganic

436518, 435 721, 435 4052, G01N 33553

Patent

active

059727209

ABSTRACT:
The invention concerns a composition comprising colloidal particles to the surface of which biomolecules are adsorbed, wherein the composition additionally contains a polyethylene glycol substituted by thiol or/and disulfide groups. This composition can be used as a detection reagent in immunological test methods.

REFERENCES:
patent: 5294369 (1994-03-01), Shigekawa et al.
patent: 5376556 (1994-12-01), Tarcha et al.
Grosdemange et al. XP-002063516 "Formation of Self-Assembled Monolayers by Chemisorption of Derivatives of Oligo (ethylene glycol) of Structure HS(CH.sub.2).sub.11 (OCH.sub.2 CH.sub.2).sub.m OH on Gold"; American Chemical Society 113, Nr.1 1991; pp. 13-20.
Prime et al. XP-002063517 "Self-Assembled Organic Monolayers: Model Systems for Studying Adsorption of Proteins at Surfaces"; Science (May 1991) pp. 1164-1167.

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