Stabilization of mercury-containing preservatives in ophthalmic

Details Stabilization of mercury-containing preservatives in ophthalmic Stabilization of mercury-containing preservatives in ophthalmic

1987-04-14

1989-05-09

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heavy metal containing doai

514669, 514914, 514970, A61K 3134, A61K 3113

Patent

active

048290831

ABSTRACT:
The invention relates to the stabilization of mercury-containing preservatives in liquid or gel-form ophthalmic medicaments. This stabilization against chemical decomposition after the preservative has become deposited on the inner walls of the plastics containers is achieved by adding to the formulation 2-amino-2-hydroxymethyl-1,3-propanediol or a homologue thereof having up to 10 carbon atoms.

REFERENCES:
patent: 2958625 (1960-11-01), Rebold
patent: 3297524 (1967-01-01), Chodsky et al.
patent: 4518608 (1985-05-01), Kahan
patent: 4524063 (1985-06-01), Wheeler
Dolder et al., Opthalmika, Stuttgart 1983, pp. 401-415.
The Merck Index, Tenth Edition (1983) No. 9575.

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