Stabilization of lipid:DNA formulations during nebulization

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

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Details

424450, 424 121, 435458, A61K 9127, A61K 5100, C12N 1588

Patent

active

061068594

ABSTRACT:
The present invention provides a liposomal aerosol composition, comprising a pharmaceutical compound, a cationic lipid, (c) a neutral co-lipid; and (d) tryptone. Also provided is a nebulized cationic lipid:DNA suspension useful for lipid-DNA transfections, wherein said cationic lipid is bis(guanidinium)-tren-cholesterol.

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