Stabilization of interferon against mechanical stress using thio

Details Stabilization of interferon against mechanical stress using thio Stabilization of interferon against mechanical stress using thio

1976-12-09

1978-07-11

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424 85, A61K 4502

Patent

active

041001508

ABSTRACT:
The present invention encompasses a method for stabilizing interferon during purification, concentration, packaging, filtering and storage comprising treating an interferon preparation with an effective stabilizing amount of reduced glutathione, thiodiglycol, thioethanolamine, thioalkanoic acid having 1-7 carbon atoms, monothioglycerol, dithiothreitol, thioctic acid, N-acetylcysteine, or N-acetyl-homo-cysteine, as a sulfur containing reducing agent for selectively retaining interferon thiols in the reduced state. The method of the present invention preserves the activity of interferon by selectively retaining interferon sulfhydryl (SH) functions in the reduced state without reducing interferon disulfide linkages (--S--S--) which are essential for activity, or by selectively blocking interferon sulfhydryl groups.

REFERENCES:
patent: 3981991 (1976-09-01), Stewart et al.
Nature, vol. 203, Sep. 1964, Fantes et al., pp. 1048-1050.
Nature, vol. 249, May, 1974, Stewart et al., pp. 460-461.
Proc. Soc. Exp. Biol. & Med. 146, 249-253 (1974), Edy et al.

Affiliated with

Also associated with

Rating

Stabilization of interferon against mechanical stress using thio does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Stabilization of interferon against mechanical stress using thio, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stabilization of interferon against mechanical stress using thio will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-261547