Stabilization of insulin through ligand binding interations

Details Stabilization of insulin through ligand binding interations Stabilization of insulin through ligand binding interations

1995-01-26

1998-11-03

Hill, Jr., Robert J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Insulin; related peptides

530304, 530305, 514 2, 514 3, 514 4, A61K 3828, C07K 500, C07K 700, C07K 1600

Patent

active

058309993

ABSTRACT:
Insulin formulations containing ligands for the insulin hexamer which bind several orders of magnitude more tightly to the hexamer than chlorine ion or acetate ion. These ligands are aliphatic and aromatic carboxylates having a dissociation constant (K.sub.D) of less than about 5 mM, and preferably less than about 1 mM. The increased tightness of binding conveys additional stability to the insulin hexamers, improving their usefulness in slow release and fast acting formulations (for example, for the treatment of diabetics).

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