Stabilization of human interferon

Details Stabilization of human interferon Stabilization of human interferon

1991-11-08

1993-08-17

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Lymphokine

Interferon

424 854, 530351, A61K 4502

Patent

active

052367070

ABSTRACT:
Described herein are compositions for stabilizing human interferon, including pharmaceutical preparations useful in topical applications. Amine stabilizing agents such as primary aliphatic amines and anionic stabilizing agents such as lithium organo sulfates protect human interferons from degradation and provide enhanced storage stability. These stabilizing agents containing interferon can be added to appropriate pharmaceutical carriers for topical applications. The topical products also exhibit enhanced storage stability.

REFERENCES:
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patent: 4675184 (1987-06-01), Hasegawa et al.
patent: 4680175 (1987-07-01), Estis et al.
patent: 4957734 (1990-09-01), Miller
patent: 5165921 (1992-11-01), Ganesh et al.
Stewart et al., Proc. Natl. Acad. Sci. 74:4200 (1977).
Stewart II, W. E., pp. 17-18 The Interferon System, Springer-Verlag (2nd Ed. 1981).
Adolf et al., J. Interferon Res. 10 (Supp. 1):S57 (1990).
Stewart and Stewart, Virology 97:473 (1979).

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