Stabilization of growth hormones

Details Stabilization of growth hormones Stabilization of growth hormones

1986-05-16

1989-03-28

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Hormones, e.g., prolactin, thymosin, growth factors, etc.

530397, 530362, 530363, C07K 1500, A61K 3736

Patent

active

048165689

ABSTRACT:
Growth hormones are admixed with various stabilizers to provide for the decreased formation of insolubles and preservation of the soluble bioactivity of the growth hormone in aqueous environments. Examples of such stabilizers include certain polyols, amino acids, polymers of amino acids having a charged side group at physiological PH, and choline salts.

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Gekko, K., and S. N. Timasheff, Biochemistry, pp. 4677-4686 (1981).

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