Stabilization of Factor VIII activity in whole blood or blood pl

Details Stabilization of Factor VIII activity in whole blood or blood pl Stabilization of Factor VIII activity in whole blood or blood pl

1980-11-26

1982-11-16

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

260112B, 260112R, 424177, A61K 3514

Patent

active

043594638

ABSTRACT:
A method whereby initial Factor VIII activity normally present in blood collected into an anticoagulant which functions by chelating calcium is maintained for twenty-four or more hours without the necessity of the usual immediate freezing in either the whole blood or blood plasma. The method comprises mixing freshly collected blood or blood plasma prepared from that blood or freshly obtained blood plasma obtained by plasmapheresis, which blood or blood plasma has been collected into a calcium chelating anticoagulant, with a calcium-heparin solution in sufficient quantities to restore calcium to substantially normal physiological levels.

REFERENCES:
patent: 4203891 (1980-05-01), Rock
Weiss-Thrombosis et Diethesis Haemorrhagica, vol. 14, No. 32, (1965) pp. 32-51.
Pepper et al.-Transfusion, vol. 18, No. 6, (Nov.-Dec. 1978) pp. 756-760.
Article by Penick, et al., "Relative Stability of Plasma Antihemophilic Factor (AHF) under Different Conditions of Storage" appears at p. 1, line 18, et seq., of the Specification.
Article by Wolf-"Studies of Temperature and pH Stability of Human Antihaemophilic Factor (AHF) in Plasma and in Concentrate" is mentioned in the Spec. at p. 2, line 4, et seq.
Article by Preston-"The Factor-VIII Activity in Fresh and Stored Plasma" is mentioned in the Specification at p. 2, line 9, et seq.
Article by Vermeer, et al.,-"Contributions to the Optimal Use of Human Blood" is Mentioned in the Specification at p. 2, line 24, et seq.

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