Stabilization of enteric coated dosage form

Details Stabilization of enteric coated dosage form Stabilization of enteric coated dosage form

1989-07-14

1991-11-26

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424462, A61K 962

Patent

active

050681109

ABSTRACT:
The present invention is a stabilized enteric-coated pharmaceutical dosage form and processes for the preparation thereof. Dissolution stability after storage of the dosage form under high stress conditions is improved by an enteric-coated dosage form having an enteric coating wherein the coating is of the acrylic resin kind of from 14 mg/cm.sup.2 to 24 mg/cm.sup.2 or an enteric coating wherein the coating is of the acetate kind of from 14 mg/cm.sup.2 to 24 mg/cm.sup.2 and having a second coating of hydrophilic coating for example, hydroxypropyl cellulose, hydroxymethyl cellulose or hydroxypropylmethyl cellulose.

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R. E. Pendell, "From solvents to aqueous coatings", Drug Develop. Ind. Pharm., 10, 191 (1984).
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EPO Search Report with attachments.

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