Stabilization of ascorbic acid, ascorbic acid derivatives and/or

Details Stabilization of ascorbic acid, ascorbic acid derivatives and/or Stabilization of ascorbic acid, ascorbic acid derivatives and/or

1998-10-30

2000-08-29

MacMillan, Keith D.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Cosmetic, antiperspirant, dentifrice

514844, 514474, 424 59, 424401, 424456, A61K 906, A61K 948, A61K 3170

Patent

active

061104779

ABSTRACT:
A stable composition is provided to treat and/or prevent photo-aged skin and related skin disorders such as sunburn, wrinkles, poor skin tone and skin discoloration by topically applying to the skin the treatment composition containing an effective amount of a compound such as ascorbic acid, derivatives of ascorbic acid and/or extracts containing ascorbic acid, in a pharmaceutically acceptable vehicle containing a substantially anhydrous base having no water added. The anhydrous base stabilizes the compound, so that the compound remains effective for an effective period of time, even in the presence of exposure to water. Preferably, the anhydrous base is a single phase carrier, as opposed to a two phase carrier emulsion.

REFERENCES:
patent: 4938969 (1990-07-01), Schinitsky et al.
patent: 5140043 (1992-08-01), Darr et al.
patent: 5587149 (1996-12-01), Punto et al.
Chemical Publishing NY., Harry's Cosmeticology 7th Edition, Chapter 38.
Interscience Publishers, Inc., NY 1957; Cosmetics Science and Technology, Chapter 42.

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