Stabilization of active plasminogen activator inhibitor-1

Details Stabilization of active plasminogen activator inhibitor-1 Stabilization of active plasminogen activator inhibitor-1

1992-01-14

1994-03-01

Wityshyn, Michael G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 27, 514822, 530380, 530381, 530382, 530350, 530395, 530402, 530427, A61K 3700, A61K 3514

Patent

active

052907643

ABSTRACT:
Processes for stabilizing active PAI-1 protein comprising combining active PAI-1 protein with an aqueous buffer having an ionic strength of at least about 5 millisiemens and a sugar selected from the group consisting of monosaccharides and disaccharides, and/or subjecting the active PAI-1 protein to lyophilization, are disclosed. Also described are compositions, including pharmaceutical compositions and kits, which include the stabilized active PAI-1 protein, and therapeutic processes employing the same in the treatment of fibrinolysis.

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