Stabilization of a mutant microorganism population

Details Stabilization of a mutant microorganism population Stabilization of a mutant microorganism population

1983-04-11

1987-04-14

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435136, 435248, 435249, 435253, C12N 1100, C12N 120, C12P 740, C12P 744

Patent

active

046578633

ABSTRACT:
This invention provides a process for stabilizing a population of a mutant microorganism in a bioconversion system whereby growth of revertant cells is suppressed.
The process involves limiting a nutrient which is essential for cell growth so that the cells selectively grow on a growth carbon source rather than on a non-growth carbon source which is present. The revertant cells being suppressed have a similar ability as the parent strain of the mutant microorganism to grow on the non-growth carbon source in the bioconversion system.
The non-growth carbon source in the bioconversion system is metabolized to an extracellular accumulating quantity of a desired metabolite, e.g., toluene is converted to muconic acid.

REFERENCES:
patent: 2822319 (1958-02-01), Monod
patent: 4355107 (1982-10-01), Maxwell
patent: 4399220 (1983-08-01), Smiley
patent: 4480034 (1984-10-01), Hsieh
patent: 4535059 (1985-08-01), Hseih et al.
Froment et al, Chem. Reactor Analysis and Design 1979, pp. 593-594, John Wiley Publisher.

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