Stabilization and oral delivery of calcitonin

Details Stabilization and oral delivery of calcitonin Stabilization and oral delivery of calcitonin

1996-06-28

1998-03-10

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 530307, A61K 3800, A61K 3802, A61K 3830, C07K 500

Patent

active

057261547

ABSTRACT:
Compositions and methods for stabilization and oral delivery of human calcitonin are described. An aqueous liquid composition for stable storage of human calcitonin comprises an aqueous mixture of SDS and an organic acid. An nonaqueous liquid composition for stable storage of human calcitonin comprises about 90-100% by volume of a mixture of C.sub.8 /C.sub.10 mono- and di-glycerides and about 0-10% by volume of a polar, nonaqueous solvent. Both of these stabilized human calcitonin formulations provided significant intestinal absorption of calcitonin.

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