Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Reexamination Certificate
2005-01-18
2005-01-18
Allen, Marianne P. (Department: 1631)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
C435S006120, C435S069100, C435S320100, C536S023500, C530S350000
Reexamination Certificate
active
06844190
ABSTRACT:
Genes encoding the St-B17 serotonin receptor protein were cloned and characterized from a rat striatum mRNA and a human genomic library. The St-B17 receptor has nucleotide and amino acid homology with previously described 5-HT genes and can bind ligands that are known to interact with serotonin receptors. In addition, the levels of intracellular cAMP in cells transfected with the receptor gene respond in a dose dependent manner to introduction of serotonin in the media.
REFERENCES:
patent: 4985352 (1991-01-01), Julius et al.
patent: 5472866 (1995-12-01), Gerald et al.
patent: WO 9117174 (1991-11-01), None
Hen, R., Of mice and flies: commonalities among 5-HT receptors. Trends in Pharmacological Sciences, 1992, vol. 13, pp 160-165.
Kohen, R., et al., Cloning, characterization, and chromosomal localization of a human 5-HT6serotonin receptor, J. Neurochemistry, 1996, vol. 66, pp. 47-56.
Monsma, F., et al., Cloning and expression of a novel serotonin receptor with high affinity to tricyclic psychotropic drugs, Mol. Pharm, 1993, 43(3), pp. 320-327.
Ruat, M., et al., A novel rat serotonin (5-HT6) receptor molecular clongin, localization and stimulaton of camp accumulation, BBRC. 1993. vol. 193(1). pp. 268-276.
Hamblin Mark
Monsma, Jr. Frederick J.
Sibley David R.
Allen Marianne P.
Knobbe Martens Olson & Bear LLP
The United States of America as represented by the Department of
LandOfFree
St-B17 serotonin receptor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with St-B17 serotonin receptor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and St-B17 serotonin receptor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3419696