Ssx-2 peptides presented by hla class II molecules

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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Reexamination Certificate

active

07910696

ABSTRACT:
The invention describes HLA class II binding peptides encoded by the SSX-2 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the SSX-2 gene.

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Wagner, Claudia et al., “Identification of HLA-A*0201 binding antigenic peptides derived from the HOM-MEL-40/SSX-2 antigen that stimulate CTL from patients with SSX-2 positive cancers,” Proceedings of the American Association for Cancer Research Annual Meeting; Mar. 2002; vol. 43, p. 606.

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