Sso7-polymerase conjugate proteins

Details Sso7-polymerase conjugate proteins Sso7-polymerase conjugate proteins

2002-10-23

2010-02-23

Hutson, Richard G (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C435S183000, C435S069100, C435S455000, C530S350000, C530S358000, C536S023100, C536S023200, C536S023400, C536S023700

Reexamination Certificate

active

07666645

ABSTRACT:
This invention provides Sso7-polymerase conjugates that exhibit improved activity in a polymerase reaction.

REFERENCES:
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patent: 6228628 (2001-05-01), Gelfand et al.
patent: WO 01/92501 (2001-12-01), None
Ngo et al., Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox, in The Protein Folding Problem and Tertiary Structure Prediction, 1994, Merz et al. (ed.), Birkhauser, Boston, MA, pp. 433 and 492-495.
Wang et al., Nucleic Acids Research, vol. 32, pp. 1197-1207, 2004.
Consonni. R. et al., “A Single-Point Mutation in the Extreme Heat- and Pressure-Resistant Sso7d Protein fromSulfolobus solfactaricusLeads to a Major Rearrangement of the Hydrophobic Core,”Biochemistry, 1999, pp. 12709-12717, vol. 38, American Chemical Society.
Gao, Y-G, et al., “The crystal structure of the hyperthermophile chromosomal protein SS07D Bound to DNA,”Nature Structural Biology, vol. 5(9), pp. 782-786 (1998).
Wang, Y., et al., “A novel strategy to engineer DNA polymerases for enhanced processivity and improved performance in vitro,”Nucleic Acids Research, vol. 32(3), pp. 1197-1207.
Agback. Peter, et al.; “Architecture of Nonspecific Protein-DNA Interactions in the Sso7d-DNA Complex; ”Nature Structural Biology; Jul. 1998; pp. 579-584; vol. 5; No. 7.
Baumann, Herbert, et al.; “DNA-Binding Surface of the Sso7d Protein from Sulfolobus Solfataricus”J. Mol. Biol,; 1995; pp. 840-846; vol. 247; Academic Press Limited.
Catanzano, Francesca, et al.; “Differential Scanning Calorimetry Study of the Thermodynamic Stability of Some Mutants of Sso7d from Sulfolobus Solfataricus;”Biochemistry; 1998; pp. 10493-10498; vol. 37; No. 29; American Chemical Society.
Gao, Yi-Gui, et al.; “The Crystal Structure of the Hyperthermophile Chromosomal Protein Sso7d Bound to DNA;”Nature Structural Biology; Sep. 1998; pp. 782-788; vol. 5; No. 9.

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