Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Patent
1997-03-06
1999-10-12
Campell, Bruce R.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
800 21, 435 6, 435 29, 4353201, 435325, 536 241, 536 2431, 935 6, 935 36, C12N 500, C12N 1500, C07H 2104
Patent
active
059657901
ABSTRACT:
The invention features nucleic acid molecules that are involved with (e.g. activate or regulate) human SR-BI receptor transcription, as well as complements thereto, and homologs thereof. In addition, drug discovery assays are provided for identifying agents which modulate SR-BI promoter activity and thereby modulate the expression of a gene regulated thereby. Such agents can be useful therapeutically for treating or preventing the development of a disease or condition that is caused or contributed to by an aberrant SR-BI activity. In a preferred embodiment, the disease or condition is characterized by inappropriate lipid transfer or metabolism (e.g., atherosclerosis or gallstone formation). Such agents can also be used to modulate expression of a specific gene under the control of the SR-BI promoter in gene therapy. Moreover, the present invention provides diagnostic assays and reagents for determining whether a subject has a disorder involving, for example, aberrant expression of SR-BI genes.
REFERENCES:
patent: 5354557 (1994-10-01), Oppermann et al.
Acton, S.L. et al. "Expression Cloning of SR-BI, a CD36-related Class B Scavenger Receptor" J. Biol. Chem. 269(33):21003-21009, 1994.
Acton, S. et al. "Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor" Science 271:518-520, 1996.
Calvo, D. and Vega, M.A. "Identification, primary structure, and distribution of CLA-1, a novel member of the CD36/LIMPH gene family" J. Biol. Chem. 268(25):18929-18935, 1993.
Calvo, D. et al. "The CD36, CLA-1 (CD36L1), and LIMPII (CD36L2) Gene Family: Cellular Distribution, Chromosomal Location, and Genetic Evolution" Genomics 25:10-106, 1995.
Fukasawa, M. et al. "SRB1, a Class B scavenger receptor, recognizes both negatively charged liposomes and apoptotic cells" Exper. Cell Research 222:246-250, 1996.
Rigotti, A. et al. "The Class B Scavenger Receptors SR-BI and CD36 are Receptor for Anionic Phospholipids" J. Biol. Chem. 270 (27):16221-16224, 1995.
Tang, Y. et al. "Identification of a Human CD36 Isoform Produced by Exon Skipping" J. Biol. Chem 269 (8):6011-6015, 1994.
Wang, N. et al. "Scavenger Receptor BI (SR-BI) is up-regaulated in adrenal gland in apolipoprotein A-I and hepatic lipase knock-out mice as a response to deplation of cholesterol stores" J. Biol. Chem 271 (35):21001-21004, 1996.
Campell Bruce R.
Millennium Pharmaceuticals Inc.
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