Squaramide derivatives as CXCR2 antagonist

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Reexamination Certificate

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Details

C544S336000, C546S329000, C548S375100, C549S074000, C549S491000, C549S505000, C564S086000

Reexamination Certificate

active

07989497

ABSTRACT:
The present invention relates to compounds of formula (I)wherein X, R1, R2, R3, R4and R5are as defined herein, which are useful for treating diseases which respond to CXCR2 receptor mediators. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

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Yun Feng Xie et al., “Structure-activity relationships of novel, highly potent, selective, and orally active CCR1 antogonists,” Bioorganic & Medicinal Chemistry Letters 15:3367-3372 (Apr. 5, 2007).

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