Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-03-21
1992-07-21
Chan, Nicky
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549363, A61K 31335, C07D31908
Patent
active
051323206
ABSTRACT:
This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthetase inhibitors and thus useful as cholesterol lowering agents.
REFERENCES:
patent: 4871721 (1989-10-01), Biller
S. A. Biller et al, J. Med. Chem., 31, 1869 (1988).
C. D. Poulter et al, J. Am. Chem. Soc., 111, 3734 (1989).
E. J. Corey et al, J. Am. Chem. Soc., 98, 1291 (1976).
Bergstrom James D.
Dufresne Claude
Hensens Otto D.
Huang Leeyuan
Onishi Janet C.
Chan Nicky
DiPrima Joseph
Merck & Co. , Inc.
Winokur Melvin
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