Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-05-17
1992-08-04
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3144
Patent
active
051359359
ABSTRACT:
Compounds of structural formula (I): ##STR1## are squalene synthestase inhibitors useful in inhibiting the biosynthesis of cholesterol in the treatment of hypercholesterolemia and related disorders.
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Ma et al. PNAS 83 8370-8374 (1986).
Swain et al., J. Med. Chem. Soc. 34 140-151 (1991).
Saunders et al., J. Med. Chem. 33 1128-1138 (1990).
Alberts Alfred W.
Berger Gregory D.
Bergstrom James D.
DiPrima Joseph F.
Jordan Kimberly R.
Merck & Co. , Inc.
Nicholson William H.
Waddell Frederick E.
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