Squalene synthetase inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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A61K 3144

Patent

active

051359359

ABSTRACT:
Compounds of structural formula (I): ##STR1## are squalene synthestase inhibitors useful in inhibiting the biosynthesis of cholesterol in the treatment of hypercholesterolemia and related disorders.

REFERENCES:
patent: 4806564 (1989-02-01), Chabala et al.
patent: 4900754 (1990-02-01), Regan et al.
Ma et al. PNAS 83 8370-8374 (1986).
Swain et al., J. Med. Chem. Soc. 34 140-151 (1991).
Saunders et al., J. Med. Chem. 33 1128-1138 (1990).

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