Spring-loaded hydraulically active liquid chromatography column

Details Spring-loaded hydraulically active liquid chromatography column Spring-loaded hydraulically active liquid chromatography column

1997-12-17

1999-07-06

Therkorn, Ernest G.

Liquid purification or separation

With means to add treating material

Chromatography

210656, B01D 1508

Patent

active

059193611

ABSTRACT:
The adsorbent bed (25) retained in an HPLC column (1) is maintained in a constant state of compression by a spring loaded hydraulically active second column (13). A relatively small spring (14) loaded piston (15) in the second column maintains a constant hydraulic pressure in the hydraulic chamber (3) of the larger diameter HPLC column (1). Multiple small diameter columns (13) can be employed if necessary.

REFERENCES:
patent: 3706812 (1972-12-01), DeRosset et al.
patent: 4675105 (1987-06-01), Martin
patent: 4769141 (1988-09-01), Couillard
patent: 5013433 (1991-05-01), Shalon
patent: 5158676 (1992-10-01), Kreher
patent: 5169522 (1992-12-01), Shalon et al.
patent: 5565104 (1996-10-01), Priegnitz
patent: 5635072 (1997-06-01), Moran
"Optical resolution by simulated moving-bed adsorption technology," Journal of Chromatography, 590 (1992) pp. 113-117.
"A spring-loaded preparative HPLC column," American Laboratory, Sep. 1997, pp. 1-4.

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