Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing
Patent
1995-06-07
1999-11-30
Lovering, Richard D.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
424 95, 424 96, 424 46, 424 943, 424 944, 424491, 424499, 514965, A61K 3843, A61K 914, A61K 950
Patent
active
059938056
ABSTRACT:
Microparticles of a water-soluble material, which are smooth and spherical, and at least 90% of which have a mass median particle size of 1 to 10 .mu.m, and which carry a therapeutic or diagnostic agent can successfully be used in dry powder inhalers to deliver the said agent.
REFERENCES:
patent: 2739167 (1956-03-01), Conn
patent: 2797201 (1957-06-01), Veatch et al.
patent: 3501419 (1970-03-01), Bridgeford et al.
patent: 3664963 (1972-05-01), Pasin
patent: 3809294 (1974-05-01), Torgeson
patent: 3937688 (1976-02-01), Zolle
patent: 4089800 (1978-05-01), Temple
patent: 4093709 (1978-06-01), Choi et al.
patent: 4107288 (1978-08-01), Oppenheim et al.
patent: 4127622 (1978-11-01), Watanabe et al.
patent: 4131648 (1978-12-01), Choi et al.
patent: 4138344 (1979-02-01), Choi et al.
patent: 4147767 (1979-04-01), Yapel et al.
patent: 4180646 (1979-12-01), Choi et al.
patent: 4247406 (1981-01-01), Widder et al.
patent: 4276885 (1981-07-01), Tickner et al.
patent: 4316341 (1982-02-01), Ticker et al.
patent: 4349530 (1982-09-01), Royer
patent: 4357259 (1982-11-01), Senyei et al.
patent: 4420442 (1983-12-01), Sands
patent: 4442843 (1984-04-01), Rasor et al.
patent: 4466442 (1984-08-01), Hillman et al.
patent: 4572203 (1986-02-01), Feinstein
patent: 4649911 (1987-03-01), Knight et al.
patent: 4671954 (1987-06-01), Goldberg et al.
patent: 4675381 (1987-06-01), Bichon
patent: 4774958 (1988-10-01), Feinstein
patent: 4808408 (1989-02-01), Baker et al.
patent: 4832941 (1989-05-01), Berwing et al.
patent: 4844882 (1989-07-01), Widder et al.
patent: 4888398 (1989-12-01), Bichon et al.
patent: 4892733 (1990-01-01), Bichon et al.
patent: 4900540 (1990-02-01), Ryan et al.
patent: 4957656 (1990-09-01), Cerny et al.
patent: 4960351 (1990-10-01), Kendall, Jr. et al.
patent: 4968562 (1990-11-01), Delgado
patent: 4981625 (1991-01-01), Rhim et al.
patent: 5089181 (1992-02-01), Hauser
patent: 5137928 (1992-08-01), Erbel et al.
patent: 5190982 (1993-03-01), Erbel et al.
patent: 5196183 (1993-03-01), Yudelson et al.
patent: 5205287 (1993-04-01), Erbel et al.
patent: 5380519 (1995-01-01), Schneider et al.
patent: 5425366 (1995-06-01), Reinhardt et al.
patent: 5501863 (1996-03-01), Rossling et al.
patent: 5518709 (1996-05-01), Sutton et al.
Sato et al., "Porous Biodegradable Microspheres for Controlled Drug Delivery. I. Assessment of Processing Conditions and Solvent Removal Techniques," Pharm. Res. 5(1):21-30 (1988).
Scheffel et al., "Albumin Microsheres for Study of the Reticuloendothelial System," J. of Nucl. Med. 13(7):498-503 (1972).
Schneider et al., "Polymeric Microballons as Ultrasound Contract Agents Physical and Ultrasonic Properties Compared with Sonicated Albumin," Invest. Radiol. 27:134-139 (Feb. 1992).
Schroderer et al., "Distribution of Radiolabeled Subvisible Microspheres After Intravenous Administration of Beagle Dogs," J. of Pharmaceutical Science 67(4):504-507 (Apr. 1977).
Shapiro et al., "Intravenous Contrast Echocardiography With Use of Sonicated Albumin in Humans: Systolic Disappearance of Left Ventricular Contrast After Transpulminary Transmission," JACC 16(7):1603-1607 (Dec. 1990).
Takenaka et al., "Mechanical Properties, Dissolution Behavior and Stability to Oxidation of .sub.L -Ascorbylmonstearate Microcapsule Prepared by a Spray-Drying Polycondensation Techniques," Chem. Pharm. Bull. 30(6):2189-2195 (1982).
Wheatley et al., "Contrast Agents for Diagnostic Ultrasound: Developement and Evaluation of Polymer-Coated Microbubbles," Biomaterials 11:713-717 (Nov. 1990).
Widder et al., "Magnetically Responsive Microspheres and Others Carriers for the Biophysical Targeting of Antitumor Agents," Advances in Pharmacology and Chemotheraphy 16:213-269 (1979).
Grinstaff, M.W., and Suslick, K.S., "Air-Filled Proteinaceous Microbubbles: Synthesis of an Echo-Contrast Agent," Proc. Natl. Acad. Sci. USA 88:7708-7710 (Sep. 1991).
Kondo, A., "Microcapsule Processing and Technology," Van Valkenburg, J.W. (Ed.), New York: Marcel Dekker, Inc., pp. 18-20, 61, 68, 70, 90-92, 106-109, 118-119 (1980).
Aldrich and Johnstion, "Use of the Spinning Disk Technique to Produce Monodisperse Microsheres of Human Serum Albumin for Labeling with Radioisotopes," Int. J. of Appl. Rad. and Isot. 25:15-18 (1974).
Allcock, "Polyphosphazenes: New Polymers iwth Inorganic Backbone Atoms," Science 193:1214-1219 (1976).
Angeloni et al., "The Mannich Bases in Polymer Synthesis: 3.* REduction of Poly(.beta.-Aminoketone)s to Poly(.gamma.-Aminoalcohl)s and Their N-Alkylation to Poly(.gamma.-Hydroxyquaternary Ammonium Salt)s," Polymer 23:1693-1697 (1982).
Buchanan et al., "Labeling Albumin Microspheres with .sup.113m In," J. of Nucl. Med. 10(7):487-490 (Jan. 1969).
Conte et al., "Spray Dried albumin Microspheres Containing Nicardipine," European J. of Pharmaceutics Biopharmaceutics 40(4):203-208 (Aug. 1994).
Ellison, "Adaptation of the Spinning Top Generator to Provide Aerosols in the Respirable Range," Ann. Occup. Hyg. 10:363-367 (1967).
Feinstein et al., "Microbubbles Dynamics Visualized in the Intact Capillary Circulation," JACC 4(3): 595-600 (Sep. 1984).
Galyean and Cotterill, "Chromatography and Electrophoresis of Native and Spray-Dried Egg White," J. Food Science 44:1345-1349 (1979).
Gramiak et al., "Ultrasound Cardiography: Contrast Studies in Anatomy and Function," Radiology 92:939-948 (1969).
Gupta and Hung, "Albumin Microspheres I:Physico-Chemical Characteristics," J. Microencap.6:427-462 (1989).
Haghpanah et al., British Pharmaceutical Conference, King's College, London (1994).
Heller, "Controlled Release of Biologically Active Compounds From Bioerodible Polymers," Biomaterials 1:51-57 (1980).
Kawashima et la., "Preparation of Multiple Unit Hollow Microspheres (Microballoons) With Acreylic Resin Containing Tranilast and Their Drug Release Characteristics (in Vitro) and Floating Behavior (in Vivo)," J. of Controlled Release 16:297-290 (1991).
Kramer, "Albumin Microspheres as Vehicles for Achieving Specificity in Drug Delivery," J. of Pharmaceutical Science 63(10):1646-1647 (1974).
Modler et al., "Calcium as an Adjuvant for Spray-Drying Acid Whey," J. Dairy Sci. 61:294-299 (1978).
Ophir et al., "Ultrasonic Backscatter From Contrast Producing Collagen Microsphere," Ultrasonic Imaging 2:67-77 (1980).
Ophir et al., "Aqueous Solutions as Potential Ultrasonic Contrast Agents," Ultrasonic Imaging 1:265-279 (Jul. 1979).
Parkinson, "Effects of Spray-Drying and Freezing on the Proteins of Liquid Whole Egg," J. Sci. Fd. Agric. 26:1625-1637 (1975).
Przyborowski et al., "Preparationof HSA Microsphere in a One-Step Thermal Denaturation of Protein Aerosol Carried in Gas Medium," E. J. of Nucl. Med. 7:71-72 (1982).
Raju et al., "Human Serum Albumin Microspheres for Lung Imaging-Preparation and Evalution," Isotopenpraxis 14:57-61 (1978).
Rettenmaier et al., "In Vivo Alteration of Res Phagocytosis by Magnetic Albumin Microshpere," J. Clin. Lab. Immunol. 17:99-103 (1985).
Barnhart, J., et al., "Characteristics of Albunex. Air-Filled Albumin Microspheres for Echocardiography Contrast Enhancement," Invest. Radiol. 25:s162-s164 (1990).
Baveja, S.K., et al., "Microencapsulation of soluble Pharmaceuticals," J. Microencapsulation 3:33-37 (1986).
Beller, G.A., et al., "Assessment of Regional Myocardial Perfusion by Positron Emission Tomography after Intracoronary Administration of Gallium-68 Labeled Albumin Microspheres," J. Comput. Assist. Tomogr. 3:447-452 (1979).
Cheng, K.T., et al., "The Production and Evalution of Contrast-Carrying Liposomes Made with an Automatic High-Pressure System," Invest. Radiol. 22:47-55 (1987).
Clausen, G., et al., "Distribution of blood flow in the dog kidney. III. Local uptake of 10 .mu.m and 15 .mu.m microsphere during renal vasodilation and constriction," Acta Physiol. Scand. 113:471-479 (1981).
Cremers, H.F.M., et al., "Albumin-Heparin Microspheres as Carriers for Cytostatic Agents," J. Controlled Release 11:167-179 (1990).
Deasy, P.B., "Coacervation-Phase Separation Proceduces Using Aqueous Vehicles," in: Microencapsulation and Related Drug Processes, New York: Marcel Dekker, Inc., pp. 61-69 (1984).
Durand-Keklikian, L
Heath David
Johnson Richard A.
Senior Peter J.
Sutton Andrew D.
Lovering Richard D.
Quadrant Healthcare (UK) Limited
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