Spontaneous preparation of small unilamellar liposomes

Details Spontaneous preparation of small unilamellar liposomes Spontaneous preparation of small unilamellar liposomes

1985-01-29

1986-10-28

Lovering, Richard D.

Plastic and nonmetallic article shaping or treating: processes

Encapsulating normally liquid material

Liquid encapsulation utilizing an emulsion or dispersion to...

264 43, 424 38, 4284022, 436829, B01J 1302

Patent

active

046197940

ABSTRACT:
The present invention relates to a novel advantageous process for the preparation of unilamellar liposomes in aqueous phase by converting a suitable lipid component, e.g. phosphatidic acid, into the ionic form by subjecting the lipid dispersion to a change in pH value and subsequently neutralizing it. Formation of the unilamellar liposomes is spontaneous, i.e. it takes place without additional external supply of energy. The liposomes obtainable by the process of this invention can be used therapeutically as carriers for drugs of the most widely different kind.

REFERENCES:
patent: 4145410 (1979-03-01), Sears
patent: 4224179 (1980-09-01), Schneider
patent: 4342826 (1982-08-01), Cole
patent: 4356167 (1982-10-01), Kelly
H. E. Schaeffer et al.: "Liposomes in Topical Drug Delivery", Invest. Opthal. Mol. Vis. Sci., 21, 220-227 (1982).

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