Spongy material consisting essentially of hyaluronic acid or its

Details Spongy material consisting essentially of hyaluronic acid or its Spongy material consisting essentially of hyaluronic acid or its

1992-08-05

1996-04-02

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424 7805, 424 7806, 424 7837, 424DIG7, 424437, 424400, A61K 31725, A61K 900

Patent

active

055038484

ABSTRACT:
The present invention relates to a new spongy material consisting essentially of hyaluronic acid or its derivatives. The characteristics of the new pharmaceutical preparations consist in assuring high concentrations of active principle for a long period of time, by exploiting the characteristics of slow release of the active principle.
The new pharmaceutical preparations can be utilized advantageously in all the numerous situations of microsurgical practice (in particular the ones relating to ear or in odontostomatology), in which it is necessary to use a substance that can be metabolized by the organism and is capable of making easier flap take, reepithelialization of mucous membranes, stabilization of grafts and filling of cavities.
The specific use of the new pharmaceutical preparations is particularly important and useful in the various ear pathologies and in the practice of otologic, otoneurosurgical and odontostomatological microsurgery, such as for instance repair of tympanic perforations.

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patent: 4851521 (1989-07-01), della Valle et al.
patent: 4965353 (1990-10-01), della Valle et al.
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"American Journal of Otolaryngology" vol. 7, No. 3, Jun. 1, 1986 pp. 181-186.
J. Theor. Biol. (1986) 119, 219-234: P. Weigel et al.: A Model for the Role of Hyaluronic Acid and Fibrin in the Early Events during . . . .
Lars-Eric Stenfors et al.: Exogenous Hyaluronic Acid (Healon) Accelerates the Healing of Experimental Myringotomies.
Am. Journ. of Otolaryngology pp. 181-186 7:1986: C. Laurent et al.: Hyaluronic Acid Reduces Connective Tissue Formation in Middle Ears Filled . . . .
Joint International Meeting: 3rd Meeting on Side Effects of Anti-Inflammatory Analgesic Drugs and 13th European Workshop on Inflammation: Verona (Italy) May 1991.
A. Martini et al.: Allegato N. 4: Hyaluronic Acid as Treatment of Tympanic Membrane Perforation . . . .
Acta Otorhinol, Ital., 10, 559-577, 1990: A. Martini et al.: Experimental Tympanic Membrane Perforation: natural history of healing process in rat.

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