Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-05-15
2007-05-15
Whisenant, Ethan (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C536S023100, C536S024300
Reexamination Certificate
active
11016672
ABSTRACT:
Methods for identifying transcripts and genes whose splicing is regulated by a selected splicing factor are disclosed. Unprocessed or partially processed transcripts are bound to an array of probes and contacted with one or more splicing factors. The identities of transcripts bound to splicing factors are determined.
REFERENCES:
patent: 5914267 (1999-06-01), Mertz et al.
patent: 6287768 (2001-09-01), Chenchik et al.
patent: 6309822 (2001-10-01), Fodor et al.
patent: 7109390 (2006-09-01), Lyznik et al.
patent: 2004/0009512 (2004-01-01), Ares et al.
patent: 2004/0014107 (2004-01-01), Garcia-Blanco et al.
Adams et al., ZNF265—a novel spliceosomal protein able to induce alternative splicing. The Journal of Cell Biology 154(1) : 25-32 (Jul. 2001).
Gerke et al., A protein associated with small nuclear ribonucleoprotein particles recognizes the 3′ splice site of premessenger RNA. Cell 47 (6) : 973-984 (1986).
Johnson et al., Genome-Wide survey of Human alternative Pre-mRNA splicing with exon junction microarrays. Science 302 : 2141-2144 (Dec. 2003).
Kafasla et al., Association of the 72/74-kDa proteins, members of the heterogeneous nuclear ribonucleoprotein M group, with the pre-mRNA at early stages of spliceosome assembly. Biochemical Journal 363 (Pt 3) : 793-799 (2002).
Kamma et al. Molecular characterization of the hnRNP A2/B1 proteins: Tissue-specific expression and novel isoforms. Experimental Cell Research 246 (2) : 399-411(1999).
Kikuchi et al., Expression profiles of non-small cell lung cancers on cDNA microarrays: Identification of genes for prediction of lymph-node metastasis and sensitivity to anti-cancer drugs. Oncogene 22 : 2192-2205 (2003).
Le Hir et al., Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions. Genes & Development 14(9) : 1098-1108 (May 2000).
Lopato et al., Pre-mRNA splicing in plants :Characterization of Ser/Arg splicing factors. PNAS 93 : 3074-3079 (1996).
Niranjanakumari et al., Reversible cross-linking combined with immunoprecipitation to study RNA-protein interactions in vivo. Methods 26 : 182-190 (2002).
Schaal et al., Selection and characterization of pre-mRNA splicing enhancers : Identification of novel SR protein-specific enhancer sequences. Molecular and Cellular Biology 19(3) : 1705-1719 (1999).
Tenenbaum et al. Identifying mRNA subsets in messenger ribonucleoprotein complexes by using cDNA arrays. PNAS 97(26) : 14085-14090 (Dec. 2000).
Zahler et al., SR Proteins: A Conserved Family of Pre-mRNA Splicing Factors. Genes & Develpoment 6 : 837-847 (1992).
Affymetrix Inc.
Wells Sandra E.
Whisenant Ethan
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