Splice variant of MyD88 and uses thereof

Details Splice variant of MyD88 and uses thereof Splice variant of MyD88 and uses thereof

2006-10-17

2006-10-17

Brumback, Brenda (Department: 1647)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S069100, C530S350000, C530S351000

Reexamination Certificate

active

07122656

ABSTRACT:
The present invention relates to the field of infection and inflammation and, more specifically, to the field of pathogen-induced nuclear factor kappa B activation. More specifically, a novel splice variant of MyD88, (MyD88S), which has been identified encoding a protein that inhibits LPS-induced NF-κB activation. MyD88Sis a target to inhibit the phenomenon of endotoxin-tolerance that occurs in sepsis.

REFERENCES:
patent: 4186183 (1980-01-01), Steck et al.
patent: 4217344 (1980-08-01), Vanlerberghe et al.
patent: 4235871 (1980-11-01), Papahadjopoulos et al.
patent: 4261975 (1981-04-01), Fullerton et al.
patent: 4485054 (1984-11-01), Mezei et al.
patent: 4501728 (1985-02-01), Geho et al.
patent: 4774085 (1988-09-01), Fidler
patent: 4797368 (1989-01-01), Carter et al.
patent: 4837028 (1989-06-01), Allen
patent: 4897355 (1990-01-01), Eppstein et al.
patent: 4946787 (1990-08-01), Eppstein et al.
patent: 5049386 (1991-09-01), Eppstein et al.
patent: 5173414 (1992-12-01), Lebkowski et al.
patent: 5194596 (1993-03-01), Tischer et al.
patent: 5212295 (1993-05-01), Cook
patent: 5350836 (1994-09-01), Kopchick et al.
patent: 5545806 (1996-08-01), Lonberg et al.
patent: 5587361 (1996-12-01), Cook et al.
patent: 5599797 (1997-02-01), Cook et al.
patent: 2002/0016460 (2002-02-01), Snow et al.
patent: WO 84/03564 (1984-09-01), None
patent: WO 91/16024 (1991-10-01), None
patent: WO 91/17424 (1991-11-01), None
patent: WO 93/24641 (1993-12-01), None
patent: WO 94/01131 (1994-01-01), None
patent: WO 94/04678 (1994-03-01), None
patent: WO 94/25591 (1994-11-01), None
patent: WO 94/26877 (1994-11-01), None
patent: WO 97/49805 (1997-12-01), None
patent: WO 99/60846 (1999-12-01), None
patent: WO 01/88137 (2001-11-01), None
patent: WO 03/057728 (2003-07-01), None
Benjamin et al., 1998, Development 125:1591-1598.
Vukicevic et al. 1996, PNAS USA 93:9021-9026.
Massague, 1987, Cell 49:437-8.
Pilbeam et al., 1993, Bone 14:717-720.
Skolnick et al. 2000, Trends in Biotech. 18:34-39.
Bork. 2000, Genome Research 10:398-400.
Doerks et al. 1998, Trends in Genetics 14:248-250.
Smith et al. 1997, Nature Biotechnology 15:1222-1223.
Brenner. 1999, Trends in Genetics 15:132-133.
Bork et al. 1996, Trends in Genetics 12:425-427.
Janssens et al. Curr Biol. Mar. 19, 2002 12:467-471.
PCT International Search Report, PCT/EP03/00381, dated May 8, 2003.
PCT International Preliminary Examination Report, PCT/EP03/00381, date Apr. 1, 2004.
Janssens et al., “Identification and characterization of a splice variant of MyD88,” Scandinavian Journal of Immunology, Jun. 2000, pp. 69, vol. 51, No. Supplement I.
Medzhitov et al., “MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways,” Molecular Cell, Aug. 1998, pp. 253-258, vol. 2, No. 2.
Bonnert et al., “The cloning and characterization of human MyD88: a member of an IL-1 receptor related family,” FEBS Letters, 1997, pp. 81-84, vol. 402, No. 1.
Byrd-Leifer et al., “The role of MyD88 and TRL4 in the LPS-mimetic activity of Taxol,” European Journal of Immunology, Aug. 2001, pp. 2448-2457, vol. 31, No. 8.
Takeda et al., “Roles of Toll-like receptors in innate immune responses,” Genes to Cells, Sep. 2001, pp. 733-742, vol. 6, No. 9.
Janssens et al., “Regulation of Interleukin-1- and Lipopolysaccharide-Induced NF-kappaB Activation by Alternative Splicing of MyD88,” Current Biology, Mar. 19, 2002, pp. 467-471, vol. 12, No. 6.

Affiliated with

Also associated with

Rating

Splice variant of MyD88 and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Splice variant of MyD88 and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Splice variant of MyD88 and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3719202