Splice choice antagonists as therapeutic agents

Details Splice choice antagonists as therapeutic agents Splice choice antagonists as therapeutic agents

2001-05-08

2008-07-22

Yu, Misook (Department: 1642)

Chemistry: molecular biology and microbiology

Process of mutation, cell fusion, or genetic modification

Introduction of a polynucleotide molecule into or...

C514S04400A

Reexamination Certificate

active

07402434

ABSTRACT:
The invention relates to methods and reagents for influencing alternative RNA splicing in living cells. More particularly, the invention relates to novel means for influencing RNA splice choice in living cells using polynucleotide-based reagents that compete for binding sites in nucleotide binding proteins, and novel methods for using these reagents as therapeutics.

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