Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Patent
1998-04-10
2000-08-22
Lee, Howard C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
514459, C07C21300, C07C21500
Patent
active
061075205
ABSTRACT:
The present invention is directed to the isolation and bioactive characterization of compounds isolated from the clam Spisula polynyma. These compounds include three sphingoid-type bases, spisulosines 285, 299 and 313 (1-3), each of which shows unique cytotoxicity against L1210 murine lymphocytic leukemia cells. In addition, sphingosine (also referred to as 4-sphingenine or octadeca-4-shpingenine, 4) and two related compounds, nonadeca-4-sphingenine (a one carbon longer homolog, 5) and sphinga-4,10-diene (a dehydrosphingosine deravitive, 6) were also obtained, These compounds also contribute to the cytotoxicity of the Spisula polynyma extracts, but did not cause the morphology changes observed with compounds 1-3.
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Fregeau Nancy L.
Rinehart Kenneth L.
Warwick Robert A.
Lee Howard C.
Linek Ernest V.
The Board of Trustees of the University of Illinois
White Everett
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