Spirothiazolidinyl piperazine derivatives

Details Spirothiazolidinyl piperazine derivatives Spirothiazolidinyl piperazine derivatives

1981-08-03

1984-06-26

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

546284, 548147, 424250, 424270, 544369, 544360, 544392, C07D41706

Patent

active

044567561

ABSTRACT:
Piperazinyl derivatives containing a spiro-2,4-thiazolidinedione heterocyclic component with relatively selective psychotropic properties are disclosed. The compound 2-[4-[4-(7,9-dioxo-6-thia-8-azaspiro[4.4]nonan-8-yl)butyl]-1-piperazinyl]p yridine-3-carbonitrile which has selective anti-psychotic activity constitutes a typical embodiment of the invention.

REFERENCES:
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patent: 3398151 (1968-08-01), Wu
patent: 3432499 (1969-03-01), Rice et al.
patent: 3717634 (1973-02-01), Wu et al.
patent: 4367335 (1983-01-01), Temple
Wu, et al., "Psychosedative Agents . . . " J. Med. Chem., 12, 876-881 (1969).
Wu, et al., "Psychosedative Agents 2 . . . " J. Med. Chem. 15, 477-479 (1972).
Jones, et al., "Some 5 Spirothiazolidiones" J. Chem. Soc., London, 91-92 (1946).

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