Spirosubstituted piperidines as selective melanin...

Details Spirosubstituted piperidines as selective melanin... Spirosubstituted piperidines as selective melanin...

2006-09-19

2006-09-19

Desai, Rita (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S017000, C546S018000

Reexamination Certificate

active

07109207

ABSTRACT:
The present invention discloses compounds which, are novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such MCH antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.

REFERENCES:
patent: 5908830 (1999-06-01), Smith et al.
patent: 2002/0052371 (2002-05-01), Fukami et al.
patent: WO 01 13917 (2001-03-01), None
patent: WO 01 70337 (2001-09-01), None
patent: WO 02 06245 (2002-01-01), None
Shimada, et al., “Mice lacking melanin-concentrating hormone are hypophagic and lean”Nature396:670-674(1998).
Borowsky, et al., “Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist”Nature Medicine8:825-830(2002).
PCT International Search Report for PCT/US 03/20088 (CN01594K) Jun. 26, 2003—4 Pages.

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