Spironolactone composition

Details Spironolactone composition Spironolactone composition

1987-04-06

1989-06-06

Schofer, Joseph L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514462, A61K 31585, A61K 3134, A61K 31335

Patent

active

048372110

ABSTRACT:
A pharmaceutical composition, having utility as a diuretic or aldosterone antagonist, comprising spironolactone and an aqueous homogenizingly effective amount of a material selected from the group consisting of (i) sodium carboxymethylcellulose, and (ii) a mixture of methylcellulose and a dimethylpolysiloxane polymer.
Also disclosed is a method of diuretic or hyperaldosteronism treatment by administration of such composition, e.g., by oral administration.

REFERENCES:
patent: 4108982 (1978-08-01), Amschler
patent: 4195084 (1980-03-01), Ong
patent: 4217359 (1980-08-01), Krapcho
patent: 4502989 (1985-03-01), Kamata et al.
patent: 4606909 (1986-08-01), Bechgaard et al.

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