Spiroindolinone derivatives

Details Spiroindolinone derivatives Spiroindolinone derivatives

2008-04-11

2010-11-16

Balasubramanian, Venkataraman (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C514S243000

Reexamination Certificate

active

07834179

ABSTRACT:
There are provided spiroindolinone derivatives of the formulaand pharmaceutically acceptable salts and esters thereof wherein R1, R2, R3, R4and R are as herein described. The compounds exhibit anticancer activity.

REFERENCES:
Wolff, Manfred E. “Burger's Medicinal Chemistry, 5ed, Part 1”, John Wiley & Sons, 1995, pp. 975-977.
Banker, G.S. et al, “Modern Pharmaceutices, 3ed.”, Marcel Dekker, New York. 1996, pp. 451 and 596.
J. Amer. Chem. Soc., (2005) vol. 127, p. 10130.
Chosez, L. et al,Tetrahedron, (1995) 11021-11042.
Ding et al,J. Med. Chem. (2006) 49:3432-3435.

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