Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-08-29
2009-02-24
Aulakh, Charanjit S (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S017000, C544S062000, C544S124000, C544S360000, C514S228200, C514S232800, C514S253030
Reexamination Certificate
active
07495007
ABSTRACT:
The present invention relates to spiroindolinone derivatives of the formulaand their enantiomers and pharmaceutically acceptable salts and esters thereof wherein R1, R2, R3, R4, R5, R6, R7and R8, are as herein described.The compounds have utility as antiproliferative agents, especially, as anticancer agents.
REFERENCES:
patent: 6774132 (2004-08-01), Claesson et al.
patent: WO 01/05790 (2001-01-01), None
J. Amer. Chem. Soc.(2005) 127 p. 10130.
Chen Li
Ding Qingjie
Liu Jin-Jun
Yang Song
Zhang Zhuming
Aulakh Charanjit S
Hoffmann-La Roche Inc.
Johnston George W.
Rocha-Tramaloni Patricia S.
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