Spiroindanamines and Spiroindanimides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

548410, 548411, A61K 3140, A61K 31405, C07D20996, C07D48710

Patent

active

059488077

ABSTRACT:
Compounds of formula I: ##STR1## wherein R.sup.1, R.sup.2, W, X, Y and Z have any of the values defined in the specification, and their pharmaceutically acceptable salts, are inhibitors of monoamine re-uptake and are useful for treating diseases in mammals wherein insufficient synaptic levels of monoamine are implicated. Also disclosed are pharmaceutical compositions, processes for preparing compounds of formula I, and intermediates useful for the synthesis of compounds of formula I.

REFERENCES:
patent: 4925841 (1990-05-01), Borenstein et al.
Abou-Gharbia, M.A., et al., "Synthesis of Spirofluorenes of Biological Interest", J. of Pharma. Sci., 67, 953-956, (1978).
Abou-Enein, M.N., et al., "1, 3-Substituted 2, 5-Pyrrolidinediones as Antiinflammatory Agents", Pharmaceutica Acta Helvetiae, 55 (2), 50-53, (1980). 4'-piperidines! as potential centralnervous system agents. 4. Central Nervous System Depressants", J. of Med. Chem., 21 (11), 1149-1154, (1978). 4'-piperidines! as potential central nervous system agents", J. of Med. Chem., 19 (11), 1315-1324, (1976).
Borenstein, M.R., et al., "Anticonvulsant activity of indanylspirosuccinimide Mannich bases", J. of Pharma. Sci., 76 (4), 300-302, (1987).
Borenstein, M.R., et al., "Synthesis of Spiroimides of Pharmacologic Interest", Heterocycles, 22 (11), 2433-2438, (1984).
Crooks, P.A., et al., "Synthesis and analgesic properties ofsome conformationally restricted analogues of profadol", J. of Med. Chem., 23 (6), 679-682, (1980). Med. Chem., 21 (6), 585-587, (1978).
Crooks, P.A., et al., "The synthesis and analgesic activities of some profadol", J. of Pharma. Sci., 71 (3), 291-294, (1982). Diuretic and antihypertensive properties of compounds containing a sulfur attached to nitrogen", J. of Med. Chem., 21 (4), 400-403, (1978). 4'-piperidines! as potential central nervous system agents. 2. Compounds containing a heteroatom attached to nitrogen", J. of Med. Chem., 20 (4), 610-612, (1977).
Nagai, Y., et al., "Studies on Psychotropic agents. VI. Synthesis of compounds", Chem. Pharma. Bull., 28 (5), 1387-1393, (1980).
Paul, S.M., et al., "Demonstration of specific "high affinity" binding 953-959, (1980).
Pletscher, A., "Platelets as Models for Monoaminergic Neurons", Essays in Neurochemistry and Neuropharmacology, J. Wiley & Sons, vol. 3, M.B.H. Youdim et al., eds., 49-101, (1978).
Sandberg, R., et al., "N-aminoalkylsuccinimides as local anaesthetics", Acta Pharm. Suec., 17, 177-182, (1980).
Schildkraut, J.J., et al., "Biogenic Amines and Emotion", Science, 156 (771), 21-37, (1967).
Sommerville, R., et al., "Synthesis and Pharmacological Evaluation of 553-555 (1985).
Sotiropoulou, E., et al., "Synthesis and pharamcochemistry of some new aminoketones wih local anaesthetic activity", Arzneimittel-Forschung, 44 (6), 702-706, (1994).
Strasser, v., et al., "Chemie des 2-Aminospiro 2860-2866, (1979).
Van Praag, H.M., "Neurotransmitters and CNS Disease", The Lancet, 2 (8310), 1259-1264, (1982).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Spiroindanamines and Spiroindanimides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Spiroindanamines and Spiroindanimides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Spiroindanamines and Spiroindanimides will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1804911

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.