Spirocyclopropyl amides and acids and their therapeutic...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S237500, C514S227200, C514S255010, C514S317000, C514S423000

Reexamination Certificate

active

07932245

ABSTRACT:
The present invention relates to the use of compounds of formula (I)for the treatment of epilepsy, bipolar disorder, psychiatric disorders, migraine, pain, or movement disorders, and to provide neuroprotection.

REFERENCES:
patent: 2407777 (2001-11-01), None
Remington's Pharmaceutical Sciences, Mack Publishing Co. 15thEdition, 1975, pp. 411-415.
Concellon et al., Complete Stereospecific Cyclopropanation of α,β- Unsaturated Amides Promoted by Sm/CH2I2, Angewandte Chemie Int. Ed. 2002, 41, No. 11 pp. 1917-1919, Jun. 3, 2002.
De Kimpe et al., Straightforward Synthesis of 1-Amino-2,2-dialkylcyclopropanecarboxylic Acids via Selective Saponification of 2,2-Dialkylcyclopropane-1,1-dicarboxylic Esters and Curtius Rearrangement, J. Org. Chem. 1994,vol. 59, pp. 8215-8219.
Arbale et al, “Synthesis of ethy/isopropy1/3-phenoxybenzyl/α-cyano-3-phenoxbenzyl(±)-cis-and(±)-trans-2-alkyl/aryl-4-oxo/hydroxy/acetoxy-spiro[2,5]octane and spiro[2,4]heptane-1-caboxylates,” Indian Journal of Chemistry, 29B, 568-571, (1990).

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