Spiroazacyclic compounds as monoamine receptor modulators

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C546S016000, C546S018000, C544S182000, C544S231000

Reexamination Certificate

active

06911452

ABSTRACT:
The present invention relates to 1-oxa-3,8-diaza-spiro[4.5]decan-2-one compounds as monoamine receptor modulators; compositions comprising the same; methods of inhibiting an activity of a monoamine receptor with said compounds; methods of treating a disease condition associated with a monoamine receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.

REFERENCES:
patent: 4255432 (1981-03-01), Kluge et al.
patent: 4353900 (1982-10-01), Clark
patent: 4853394 (1989-08-01), King et al.
patent: 5707798 (1998-01-01), Brann
patent: 6107324 (2000-08-01), Behan et al.
patent: 6140509 (2000-10-01), Behan et al.
patent: 6150393 (2000-11-01), Behan et al.
patent: 6358698 (2002-03-01), Weiner et al.
patent: 0061333 (1982-09-01), None
patent: WO 97/11940 (1997-04-01), None
patent: WO 99/52927 (1999-10-01), None
patent: WO 01/66521 (2001-09-01), None
Bhatia, et al., 5-Lipoxygenase inhibitors: synthesis and structure-activity relationships of a series of 1-Aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones, J. Med. Chem. 39:3938-3950 (1996).
Barchas, et al., Serotonin and Behavior (1973), (contents only, 4 pages).
Barnes & Sharp, A review of central 5-HT receptors and their function, Neuropharmacology, 38:1083-1152 (1999).
Barr & Manning, Agonist-independent activation of Gzby the 5-hydroxytryptamine1Areceptor co-expressed inspodoptera frugiperdacells, J. Biol. Chem. 272:32979-87 (1997).
Bassus et al., Psychotropes potentials. X. Synthese de butyrophenones a cycle piperidine-spiro-tetrahydrooxazinone douees d'activite neuroleptique, Eur. J. Med. Chem.—Chim. Ther. 9:416-423 (1974).
Bond et al., Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β2-adrenoceptor, Nature 374:272 (1995).
Boullin, Serotonin In Mental Abnormalities 1:316 (1978).
Caroon et al., Synthesis and antihypertensive activity of a series of 8-substituted 1-oxa-3,8-diazaspiro[4.5]decan-2-ones, J. Med. Chem. 24:1320-1328 (1981).
Cerione et al., The mammalian β2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimlatory nucleotide binding protein of the adenylate cyclase system, Biochemistry 23:4519-25 (1984).
Brann, Identification of ligands by selective amplification of cells transfected with receptors and marker enzymes, Chem. Abstr. 128:111548 (1998).
Clark et al., Antihypertensive 9-substituted 1-Oxa-4,9-diazaspiro[5.5]undecan-3-ones, J. Med. Chem. 26:855-861 (1983).
Fisera et al., Synthesis of spiro-substituted 1,3-oxazines by a new sequence leading to spiroheterocycles, Monatsh. Chem. 125:909-919 (1994).
Fuller, Drugs acting on serotonergic neuronal systems, Biology of Serotonergic Transmission, chapter 9, 221-247 (1982).
Gawley and Aubé, Pergamon, 1996, ISBN 0 08 0418759.
Gershon, et al., 5-Hydroxytryptamine and enteric neurones, in the Peripheral Actions of 5-Hydroxytryptamine, Oxford University Press, 247-273 (1989).
Glennon, Serotonin receptors: clinical implications, Neurosci. Biobehavioral Rev. 14:35-47 (1990).
Gstach et al., Rearrangement of 3,3-disubstituted 1-Aryl-4,5-dihydro-5-oxo-3H-1,2,4-triazolium Tetrafluoroborates; Part 1. A versatile synthesis of 1,5-disubstituted 2-Aryl-1,2-dihydro-3H-1,2,4-triazol-3-one Tetrafluoroborates, Synthesis 803-808 (1990).
Mavunkel et al., Synthesis and characterization of pseudopeptide bradykinin B2 receptor antagonists containing the 1,3,8-triazaspiro[4.5]decan-4-one Ring System, J. Med. Chem. 39:3169-3173 (1996).
Meltzer, The role of serotonin in antiphsycotic drug action, Neuropsychopharmacology, 21:106S-115S (1999).
Meng et al., Synthetic approaches toward glidobamine, the core structure of the glibobactin antibiotics, Tetrahedron 47:62510-6264 (1991).
Moulignier, Recepteurs centraux de la serotonine principaux aspects fondamentaux et fonctionnels application therapeutiques, Rev. Neurol. 150:3-15, (1994).
Mullen et al., (-)-Spiro[1-azabicyclo[2.2.2]octane-3,5′-oxazolidin-2′one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the α7 nicotinic acetylcholine receptor, J. Med. Chem. 43:4045-4050 (2000).
Saltzman et al., Cloning of the human serotonin 5-HT2 and 5HT1C receptor subtypes, Biochem. Biophys. Res. Comm. 181:1469-78 (1991).
Saxena, et al., Cardiovascular effects of serotonin agonists and antagonists, J. Cardiovascular Pharmacol. 15(Supp. 7):S17-S34 (1990).
Smith et al., New spiropiperdines as potent and selective non-peptide tachykinin NK2receptor antagonists, J. Med. Chem. 38:3772-3779 (1995).
Tsukamoto et al., Synthesis and structure-activity studies of a series of 1-oxa-2,8-diazaspiro[4.5]decan-3-ones and related compounds as M1muscarinic agonists, Chem. Pharm. Bull. 43(9):1523-1529 (1995).
Wiener et al., 5-Hydroxytryptamine2Areceptor inverse agonists as antipsychotics, J. Pharmacol. Exp. Ther. 299(1):268-276 (2001).
International Search Report (PCT/US02/41476), date of mailing: Aug. 5, 2003.

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