Spiro-substituted azacycles as modulators of chemokine receptor

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514212, 5142222, 5142278, 5142282, 5142288, 5142305, 514241, 514252, 514278, 514361, 514362, 514363, 514364, 514365, 514374, 514381, 514382, 514393, 514394, 514397, 514406, 514409, A61K 31435, A61K 3154, A61K 3140, A61K 31425

Patent

active

060136448

ABSTRACT:
The present invention is directed spiro-substituted azacycles of formula I: (wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, k, l and m are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.

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